The Marie Curie Training Site will prospectively resume operation on April 1, 2006.

Deadline for application: July 20, 2006.

Start of the program: October 1, 2006.

Projects

To view the research profiles of the main supervisors, please click here.

1. Autoreactive T cells and activation-induced apoptosis and detection of target genes by gene expression profiling in a murine model for multiple sclerosis

Main supervisor: W. Baumgärtner, Department of Pathology, University of Veterinary Medicine Hannover
Techniques: DNA-microarry analysis, RT-PCR, immunohistology and in situ-hybridization  

2. Genetically modified dopaminergic progenitor cells – morphometrical and functional evaluation after intrastriatal transplantation in the rat model of Parkinson´s disease

Main supervisor: C. Grothe, Department of Neuroanatomy, Medical School Hannover
Techniques: stem cell culture, transfection, in vivo experiments, morphometric evaluation, behavioural tests  

3. Mechanisms and treatment of pharmacoresistance in a rat model of temporal lobe epilepsy

Main supervisor: W. Löscher, Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover
Techniques: experimental neurophysiology, immunohistochemistry, laser scanning microscopy, behavioral pharmacology  

4. Molecular basis of the axon-oligodendrocyte interaction during remyelination

Main supervisor: M. Stangel, Department of Neurology, Medical School Hannover
Techniques: toxin induced de-/remyelination animal model, use of transgenic animals, histological methods, in situ hybridization, oligodendrocyte and neuronal cell culture, immunocytochemistry, functional tissue culture assays (for proliferation, migration, differentiation)  

5. Seasonal Changes in Cerebral Structural Plasticity

Main supervisor: S. Steinlechner, Department of Zoology, University of Veterinary Medicine Hannover
Techniques: Immunohistochemistry of steroid receptors, leptin receptors, orexigenic and anorexic peptides such as NPY and AGRP for the anabolic pathway and CART and POMC for the catabolic pathway, apoptose-specific proteins (e.g. Bcl2 and Bax), in-situ-hybridisation for detection of gene activation